Autoimmune hepatitis induced by bosentan in a patient with pulmonary arterial hypertension (RCD code: II‑1A.1; VIII)

Kalashnykova, O.S. and Vasilyeva, L.I. and Khomich, A.V. (2019) Autoimmune hepatitis induced by bosentan in a patient with pulmonary arterial hypertension (RCD code: II‑1A.1; VIII). Journal of Rare Cardiovascular Diseases, 4 (4). pp. 101-105. ISSN 2299-3711 (print), 2300-5505 (online)

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Abstract

Endothelin receptor antagonist (ERA) therapy‑induced increase in liver transaminases in patients with pulmonary arterial hyperten‑ sion (PAH) is an adverse effect of bosentan which is not fully understood. A 62‑year‑old female with a 1.5‑year history of progressively worsening dyspnoea was diagnosed with idiopathic PAH (IPAH). After 2 months of PAH treatment with bosentan, levels of liver transami‑ nases were elevated and autoimmune hepatitis was diagnosed. This clinical case demonstrates the challenge of diagnosing autoimmune hepatitis induced by ERA therapy in clinical practice. A thorough understanding of the pathogenesis and clinical presentation of autoim‑ mune hepatitis, as well as the possibility to perform specific investigations with multiple serological markers are crucial for establishing the correct diagnosis. JRCD 2019; 4 (4): 101–105

Item Type:	Article
Additional Information:	https://www.scopus.com/record/display.uri?eid=2-s2.0-85104581679&origin=resultslist&sort=plf-f&src=s&st1=Vasilyeva&nlo=&nlr=&nls=&sid=0fd7f04f0f62c7b0e55170044a79e1c8&sot=b&sdt=cl&cluster=scoaffilctry%2c%22Ukraine%22%2ct%2bscosubjabbr%2c%22MEDI%22%2ct&sl=22&s=AUTHOR-NAME%28Vasilyeva%29&relpos=2&citeCnt=0&searchTerm=#metrics
Uncontrolled Keywords:	rare disease, endothelin receptor antagonist, echocardiography, computed tomography, transaminase
Subjects:	Internal Medicine
Divisions:	Departments > Department of Internal Medicine 3 (formerly - hospital therapy 2)
Depositing User:	Елена Шрамко
Date Deposited:	17 Aug 2022 10:51
Last Modified:	17 Aug 2022 10:57
URI:	http://repo.dma.dp.ua/id/eprint/7751

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