Effect of quertine on electrolyte metabolism indicators in patients with urate nephrolithiasis comorbid with metabolic syndrome

Bilai, S.I. and Dovbysh, M.A. and Mischenko, O.M. and Dovbysh, I.M. (2022) Effect of quertine on electrolyte metabolism indicators in patients with urate nephrolithiasis comorbid with metabolic syndrome. Урологія, 26 (1). pp. 27-32. ISSN 2307-5279

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Abstract

Urolithiasis is a polyetiological disease that ranks second in the structure of causes of death from a urological pathology. An important function of the kidneys is to maintain electrolyte balance, especially that of ions such as sodium, potassium, calcium, phosphorus and others. In urate nephrolithiasis (UN), urinary sodium excretion can be both increased and decreased. Kidney damage leads to a decrease in sodium reabsorption to 80% and, accordingly, to an increase in its secretion. Damage to the glomeruli and reduction of glomerular filtration leads to sodium retention, accumulation of fluid in the body and increased 28 urologiya.dmu.edu.ua UROLOGIYA journal blood pressure. Glomerular and tubular dysfunction results in hyperphosphatemia, moderate elevations in serum magnesium, and hypocalcemia. Deterioration of phosphorus-calcium metabolism contributes to increased levels of parathyroid hormone, which is supported by a decrease in ionized calcium due to phosphorus retention and progression of various forms of osteodystrophy. The progression of renal failure against the background of UN, as well as the weakening of the adaptive reserves of the body, requires the search for the most physiological, complex-acting drugs that cause the least side effects . The greatest interest in the treatment of UN comorbid with metabolic syndrome (MS) are flavonoids, which are actively involved in purine, electrolyte, nitrogen, li pid, and carbohydrate metabolism. One of the bioflavonoids is quertine, which has membrane-stabilizing, anti-inflammatory, antioxidant and nephroprotective activity. The aim of the study is to investigate the effect of quertine on electrolyte metabolism and excretion of stone-forming compounds in patients with UN comorbid with MS.

Item Type:	Article
Additional Information:	DOI 10.26641/2307-5279.26.1.2022.260489
Uncontrolled Keywords:	urate nephrolithiasis, metabolic syndrome, electrolyte metabolism, quertine
Subjects:	Urology Endocrinology
Divisions:	University periodicals > Урологія
Depositing User:	Аліна Чеботарьова
Date Deposited:	29 Nov 2022 11:50
Last Modified:	29 Nov 2022 11:50
URI:	http://repo.dma.dp.ua/id/eprint/7964

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