Measures of Insulin Resistance as a Screening Tool for Dysglycemia in Patients With Coronary Artery Disease: A Report From the EUROASPIRE V Population

Ferrannini, G. and De Bacquer, D/ and Erlund, I. and Gyberg, V. and Kotseva, K. and Mellbin, L. and Norhammar, A. and Schnell, O. and Tuomilehto, J. and Vihervaara, T. and Wood, D. and Rydren, L. and Potabashny, V. (2022) Measures of Insulin Resistance as a Screening Tool for Dysglycemia in Patients With Coronary Artery Disease: A Report From the EUROASPIRE V Population. Diabetes Care, 45 (9). pp. 21111-21117. ISSN ISSN 0149-5992 EISSN 1935-5548

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Abstract

The optimal screening strategy for dysglycemia (including type 2 diabetes and impaired glucose tolerance) in patients with coronary artery disease (CAD) is debated. We tested the hypothesis that measures of insulin resistance by HOMA indexes may constitute good screening methods. Insulin, C-peptide, glycated hemoglobin A1c, and an oral glucose tolerance test (OGTT) were centrally assessed in 3,534 patients with CAD without known dysglycemia from the fifth European Survey of Cardiovascular Disease Prevention and Diabetes (EUROASPIRE V). Three different HOMA indexes were calculated: HOMA of insulin resistance (HOMA-IR), HOMA2 based on insulin (HOMA2-ins, and HOMA2 based on C-peptide (HOMA2-Cpep). Dysglycemia was diagnosed based on the 2-h postload glucose value obtained from the OGTT. Information on study participants was obtained by standardized interviews. The optimal thresholds of the three HOMA indexes for dysglycemia diagnosis were obtained by the maximum value of Youden’s J statistic on receiver operator characteristic curves. Their correlation with clinical parameters was assessed by Spearman coefficients.

Item Type:	Article
Additional Information:	DOI: 10.2337/dc22-0272
Subjects:	Cardiology Diabetes
Divisions:	Faculty of Postgraduate Education > Department of Therapy, cardiology and family medicine FPE
Depositing User:	Аліна Чеботарьова
Date Deposited:	12 Dec 2022 11:46
Last Modified:	12 Dec 2022 11:46
URI:	http://repo.dma.dp.ua/id/eprint/7996

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