Single Nucleotide Variants of the MCM6 Gene as a Risk Factor for Metabolically Unhealthy Obesity in Children

Abaturov, Aleksandr and Nikulina, Anna and Nikulin, Dmytro (2022) Single Nucleotide Variants of the MCM6 Gene as a Risk Factor for Metabolically Unhealthy Obesity in Children. American Heart Journal, 254. p. 249. ISSN 0002-8703 (Print), 1097-6744 (Online)

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Abstract

Background Lactose maldigestion associated with lactase non-persistence is a trigger for persistent meta-inflammation in metabolically unhealthy obesity (MUO), including arterial hypertension, atherogenic-type dyslipidemia, and insulin resistance. Aim to study the contribution of single nucleotide variants (SNV) of the gene minichromosome maintenance complex component 6 (MCM6) to the development of MUO in children. Materials and methods. 152 obese children aged 6-18 years were genotyped for the MCM6 gene (RT-PCR, Synevo, Ukraine).

Item Type:	Article
Additional Information:	https://www.sciencedirect.com/science/article/abs/pii/S000287032200240X?via%3Dihub https://doi.org/10.1016/j.ahj.2022.10.045
Subjects:	Pediatrics
Divisions:	Departments > Department of Pediatrics 1 and medical genetics (formerly - Faculty Pediatrics and Medical Genetics)
Depositing User:	Елена Шрамко
Date Deposited:	04 Jan 2023 13:13
Last Modified:	04 Jan 2023 13:13
URI:	http://repo.dma.dp.ua/id/eprint/8050

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