Structural changes in the digestive tract in a case of experimental duodenogastric reflux

Romanenko, Y. and Komskyi, M. and Lisova, I. and Sribnyk, P. and Sribnyk, T. (2022) Structural changes in the digestive tract in a case of experimental duodenogastric reflux. In: Multidisciplinary academic notes. Science research and practice. Proceedings of the ХХIV International Scientific and Practical Conference. Madrid, Spain. International Science Group, Madrid, Spain, pp. 270-272. ISBN 979-8-88680-822-3

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Abstract

Experimental reproduction of duodeno-gastric reflux was performed among Wistar line 28 rats, which were injected with 50 % solution of medical bile by intragastric way. Morphological study had been shown significant structural changes in the gingival tissues, mucous membrane of an esophagus, stomach and duodenum. Introduction. The bile or alkaline reflux is a well–known retrograde spillage of bile from duodenum into the anatomically highly situated organs – stomach, esophagus and oral cavity[1–3]. Pepsin and combination of pepsin with the conjugated bile acids in an acidic environment are the basic aggressive factors, which destroy a protective barrier of mucous membrane in the stomach and duodenum[4–7]. However, a role of bile at the appearance of esophagus and oral cavity lesions in a case of DGR is uncertain. Purpose of research – to identify structural changes in the digestive tract tissues in a case of experimental model of duodeno–gastric reflux. Material and methods. The model of reflux was reproduced with 28 immature rats of both sexes of Wistar’s line.

Item Type:	Book Section
Additional Information:	XXIV International Scientific and Practical Conference «Multidisciplinary academic notes. Science research and practice», June 21-24, 2022, Madrid, Spain URL: https://isg-konf.com/multidisciplinary-academic-notes-science-research-and-practice-two/ Available at : DOI: 10.46299/ISG.2022.1.24
Subjects:	General dentistry Gastroenterology Experimental medicine Morphology
Divisions:	Departments > Department of Pediatric Dentistry
Depositing User:	Елена Шрамко
Date Deposited:	24 Jan 2023 13:26
Last Modified:	24 Jan 2023 13:33
URI:	http://repo.dma.dp.ua/id/eprint/8106

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