Рецепторні механізми легеневого епітелію при взаємодії з патогенами різного генезу

Хріпков, І.С. and Голікова, А.А. (2022) Рецепторні механізми легеневого епітелію при взаємодії з патогенами різного генезу. Морфологія = Morphologia (2). pp. 22-30. ISSN 1997-9665

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Abstract

The respiratory system is one of the gates through which pathogens of viral or bacterial genesis enter the body. The primary contact of the pathogen with the epithelial cells of the mucous, due to interaction with the receptors of the cell, determines the direction of the body's reaction associated with the formation of an inflammatory reaction, or with the penetration of the pathogen into the cells and the use of the body's resources for its own replication and distribution in the body. The interaction of epithelial cells of the respiratory system in respiratory viral infections plays a leading role in ensuring antiviral reactions from the human body. This happens with the help of two main receptors: Toll - like and ACE2. Epithelial cells, lining the respiratory tract from the nasal cavity to the respiratory part of the lungs, respond to viral infections by producing cytokines and chemokines, which can interact with immunocompetent cells and directly with viruses. With the contact interaction of viral pathogens with the pulmonary epithelium, two multidirectional cellular receptor systems are activated, which simultaneously carry out the processes of incorporation of the virus into the target cell and activate the processes of innate and adaptive immunity, manifested at the local and systemic levels and aimed at neutralizing the viral factor and eliminating damaged cells.

Item Type:	Article
Additional Information:	DOI: 10.26641/1997-9665.2022.2.22-30
Uncontrolled Keywords:	Key words: histology, Toll - like receptors, ACE2 receptors, epithelium of conducting airway, alveolar epithelium; гістологія, Toll – подібні рецептори, ACE2 рецептори, епітелій повітряносних шляхів, респіраторний епітелій легень
Subjects:	Histology
Divisions:	Departments > Department of histology
Depositing User:	Ирина Медведева
Date Deposited:	13 Sep 2023 08:06
Last Modified:	13 Sep 2023 08:06
URI:	http://repo.dma.dp.ua/id/eprint/8541

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