The influence of extracorporeal shock wave lithotripsy on the quantity of b2-microglobulin in patients with urine stone disease and chronic pyelonephritis

Chernylovskyi, A. and Akhe, E.A. (2023) The influence of extracorporeal shock wave lithotripsy on the quantity of b2-microglobulin in patients with urine stone disease and chronic pyelonephritis. The 21th International scientific and practical conference “Scientists and methods of using modern technologies” (May 30 – June 02, 2023). pp. 180-182.

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Abstract

In recent years, Beta-2 microglobulin (B2M) has attracted special interest. This compound consists of a single polypeptide chain containing 100 amino acid residues. Most cells of living organisms, including blood cells (except erythrocytes), carry B2M on their membrane [1]. Increased levels of B2M in blood serum are observed in oncological diseases, inflammatory processes, as well as in renal tubular dysfunction and acute pyelonephritis exacerbation [2-7]. Elevated levels of B2M can also be observed in arterial hypertension (AH) [5]. Recent studies indicate that there is even a moderate positive correlation between increased B2M levels and cardiovascular diseases and mortality [5]. Urolithiasis (UL) and chronic pyelonephritis (CP) are relatively common pathologies of the urinary system. They can occur separately or concurrently, aggravating each other. Extracorporeal shock wave lithotripsy (ESWL) is one of the treatment methods for UL. There is evidence that one of the most frequent complications of ESWL is exacerbation of CP, which, in some cases, may manifest with mild clinical symptoms [6-10]. Therefore, it may be considered to determine the level of B2M before performing ESWL as a prognostic factor for pyelonephritis exacerbation/

Item Type:	Article
Subjects:	Family Medicine
Divisions:	Departments > Department of Internal Medicine
Depositing User:	Аліна Чеботарьова
Date Deposited:	18 Sep 2023 06:24
Last Modified:	18 Sep 2023 06:25
URI:	http://repo.dma.dp.ua/id/eprint/8549

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