Ways to promote the efficiency of herpetic stomatitis treatment

Lutsenko, R.V. and Moisieieva, N.V. and Ostrovska, H.Yu. and Kapustianska, A.A. (2023) Ways to promote the efficiency of herpetic stomatitis treatment. Медичні перспективи = Medicni perspektivi (Medical perspectives) (2). pp. 71-76. ISSN 2307-0404 (print), 2786-4804 (online)

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Abstract

The treatment of herpetic stomatitis should be etiotropic, pathogenetic, symptomatic, and local. The research determined the effectiveness of inosine pranobex (1000 mg 4 times a day) in herpetic stomatitis treatment. Addition of inosine pranobex to the pharmacotherapy of herpetic stomatitis reduced hospital stay and duration of treatment. The drug suppresses the synthesis of the virus due to the structure of inosinic acid in the polyribosomes of the cell affected by the virus, and also helps to eliminate the deficiency or dysfunction of immunity that occurred in the case of herpetic stomatitis, it affects the activity of T-cytotoxic lymphocytes and natural killers, enhances the action of neutrophil granulocytes, chemotaxis and phagocytosis of monocytes and macrophages, increases the synthesis of interleukins IL-1 and IL-2, affects the number of Ig G immunoglobulins. Applying inosine pranobex also significantly decreased pain syndrome manifestations from the start of the treatment. It contributed to body temperature normalization 2 days earlier which shortened the treatment period at the in-patient department. Applying inosine pranobex in the combination therapy of herpetic stomatitis has shown a potent clinical efficacy and can be an alternatіve to acyclic nucleosides in patients with herpetic stomatitis of the oral mucosa

Item Type:	Article
Additional Information:	DOI: 10.26641/2307-0404.2023.2.283255
Uncontrolled Keywords:	Key words: herpes simplex virus, herpetic stomatitis, inosine pranobex, combination therapy, immunological parameters; вірус простого герпесу, герпетичний стоматит, інозин пранобекс, комплексне лікування, імунологічні показники
Subjects:	Therapeutic dentistry
Depositing User:	Ирина Медведева
Date Deposited:	27 Sep 2023 09:59
Last Modified:	27 Sep 2023 09:59
URI:	http://repo.dma.dp.ua/id/eprint/8581

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