Kitova, I.V. and Kosharny, V.V. and Abdul-Ogly, L.V. and Kozlovskaya, G.O. and Demchenko, O.M. (2023) Dynamics of immunohistochemical changes in the lumbar spinal cord under the conditions of impactwave influence. Морфологія = Morphologia, 17 (3). pp. 45-51. ISSN 1997-9665
Full text not available from this repository. (Request a copy)Abstract
In connection with the current realities in Ukraine, combat surgical trauma became one of the most urgent problems of 2014 and increased many times. Injuries of the spine and spinal cord in the general structure of combat surgical trauma do not exceed 2%, but are accompanied by high mortality (from 19.1 to 52.9%) and permanent loss of working capacity in most cases of injuries. The purpose of our scientific work was to investigate the dynamics of microscopic changes that occur in the lumbar spinal cord during shock wave exposure using immunohistological research methods. Results. At the microscopic level, after exposure to a shock wave for 7 days, an increase in the size of neurons and interstitial space was found, which indicated the effects of the shock wave, which were more clearly accompanied by patency, hyperemia of vessels and swelling of their endothelium, which immunohistochemically confirmed more accumulation of the marker of endothelial NO-synthase in the first experimental group and a decrease in the accumulation of HIF-1ɑ, a hypoxia marker, in this experimental group, but an increase in the eNos marker in this group compared to the second and third groups, due to the activation of adaptive processes of the microcirculatory bed and the cell energy supply apparatus that occur in neurocytes after the action of the shock wave after 14 days. Conclusion. Thus, the impact of the shock wave has more morphological vascular ulcerative consequences in the acute and early periods, which have a slow but reversible nature of manifestations on the structural elements of the nervous tissue of the spinal cord, but in the late period, as a result of clearly hypoxic processes, these consequences have a more destructively progressive nature , which confirmed at the microscopic level the expression of HIF-1ɑ - a marker of hypoxia in the third experimental group.
| Item Type: | Article |
|---|---|
| Additional Information: | DOI: 10.26641/1997-9665.2023.3.45-51 |
| Uncontrolled Keywords: | spinal cord, lumbar spinal cord, immunohistochemistry, neurocyte, spinal node, neuroglia, barotrauma, blast injury |
| Subjects: | Medicine of Emergency situations Combat trauma |
| Divisions: | Departments > Department of Physiology Departments > Department of human anatomy, clinical anatomy and operative surgery University periodicals > Morphology |
| Depositing User: | Аліна Чеботарьова |
| Date Deposited: | 11 Apr 2024 12:06 |
| Last Modified: | 11 Apr 2024 12:06 |
| URI: | http://repo.dma.dp.ua/id/eprint/8838 |
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