Kozlova, Yu.V. and Maslak, H.S. and Netronina, O.V. and Abraimova, O.Ye. and Kozlov, S.V. (2024) The state of antioxidant system and emotional statusin rats with mild blast-induced traumatic brain injury. Запорожский медицинский журнал = Zaporozhye medical journal, 26 (1(142)). pp. 53-57. ISSN 2306-4145 (print), 2310-1210 (online)
Full text not available from this repository.Abstract
The aim was to evaluate the markers of emotional status and the antioxidant system activity in rats with blast-induced traumaticbrain injury.Materials and methods. The study carried out on 85 sexually mature male Wistar rats in compliance with the current legislationon humane treatment of animals. The selected rats were randomly divided into three groups: I – study in the Barnes maze; II –study in the Open Field test; and III – study of glutathione reductase activity in a solution of rat erythrocyte’s hemolysate. In eachof these groups, three groups were formed: Experimental – exposed to a shock wave with an overpressure of 26.4 ± 3.6 kPa; theSham – subjected only to halothane and fixation; and the Intact group.Results. Showed a disturbance in the emotional status and the oxidative stress development in rats with blast-induced trauma.The time of experimental rats freezing in the Barnes maze increased by 69 % (p < 0.01) on 28 th day compared to 1 st day, indicatingthe development of fear and negative emotionality. Changes in the defecation acts number indicate the development of anxietyin the acute period (1–3 days), followed by a depression-like state. The glutathione reductase activity in experimental rats wassignificantly higher compared to sham and intact rats, but gradually decreased inside in the experimental group. The results of thecorrelation analysis indicate the presence of weak relationships between the freezing time and the glutathione reductase activity.The positive relationship of a strong degree was found between the number of defecation acts and glutathione reductase on 1 stday and a negative relationship of a strong degree was found on 7 th day.Conclusions. We suppose that oxidative stress is a link, but not the leading one, in the pathogenesis of emotional disturbancein rats with blast-induced brain injury.relationships between the freezing time and the glutathione reductase activity.The positive relationship of a strong degree was found between the number of defecation acts and glutathione reductase on 1 stday and a negative relationship of a strong degree was found on 7 th day.Conclusions. We suppose that oxidative stress is a link, but not the leading one, in the pathogenesis of emotional disturbancein rats with blast-induced brain injury.
| Item Type: | Article |
|---|---|
| Additional Information: | DOI: 10.14739/2310-1210.2024.1.291777 |
| Uncontrolled Keywords: | oxidative stress,glutathionereductase,emotionality, blastinjuries, brain |
| Subjects: | Pathological physiology |
| Divisions: | Departments > Department of Biochemistry and medical chemistry Departments > Department of Pathological Anatomy and Forensic Medicine |
| Depositing User: | Аліна Чеботарьова |
| Date Deposited: | 01 Oct 2024 10:40 |
| Last Modified: | 01 Oct 2024 10:40 |
| URI: | http://repo.dma.dp.ua/id/eprint/9111 |
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