Petrenko, Yevhen and Dubossarska, Yulianna (2025) Transvaginal ultrasound cervical measurement for predicting preterm labour in singleton pregnancies. The 1st International scientific and practical conference “Innovation and development in world science” (November 3-5, 2025). pp. 81-88.
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INNOVATION-AND-DEVELOPMENT-IN-WORLD-SCIENCE-3-5.11.25-81-88.pdf Download (430kB) |
Abstract
Aim: to estimate the applicability of ultrasound parameters: cervical length (CL), uterocervical angle (UCA) and the index UCA/CL ratio in the second trimester of singleton pregnancies for predicting spontaneous preterm birth (sPTB). Materials and methods. The study group included 46 pregnant women aged 16 to 43 years. Informed consent was obtained from the patients for the conduct of the study. The main group included 22 women whose pregnancies ended in sPTB at 24-36 weeks of gestation. The control group consisted of 24 patients who had term births. Transvaginal ultrasound was performed at 18-22 weeks of pregnancy using intracavitary transducers with a frequency of 3-13 MHz. Descriptive and analytical statistical methods were used (Shapiro-Wilk test, Student's t-test, Mann-Whitney U test, Pearson's χ2 test, Fisher's exact test, Spearman's rank correlation coefficients and ROC analyses). The study was conducted in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the local ethics committee. Results. In order to assess the prognostic ability and determine the critical (threshold) levels of the studied ultrasonographic indicators measured in the second trimester of pregnancy, ROC analysis was performed to predict sPTB. It was found that the optimal threshold value of CL was ≤3.3 mm with an area under the ROC curve AUC=0.832 (95% confidence interval (CI) 0.693-0.926) at p<0.001, and sensitivity (Se) and specificity (Sp) criteria Se=72.7%, Sp=83.3%. The threshold value of UCA was determined to be an angle >93.2 degrees with an area under the ROC curve AUC=0.799 (95% CI 0.655-0.903) at p<0.001, and sensitivity and specificity criteria Se=81.8%, Sp=70.8%. According to ROC analysis, the most sensitive indicator for assessing the risk of sPTB was the index UCA/CL ratio with an optimal threshold value > 2.66 degree/mm, an area under the ROC curve AUC=0.856 (95% CI 0.721-0.942) at p<0.001, sensitivity and specificity indicators of the criterion Se=95.5%, Sp=66.7%. Conclusions. Thus, based on the results of our study, we can conclude that a combination of several transvaginal ultrasound cervical measurement in the second trimester (CL, UCA and the index UCA/CL ratio) can provide a higher level of accuracy in predicting the risk of sPTB in singleton pregnancy. We found that the optimal threshold value of CL was ≤3.3 mm, the threshold value of UCA was determined to be an angle >93.2 degrees and for the index UCA/CL ratio an optimal threshold value was established as > 2.66 degree/mm. The index UCA/CL ratio was the most sensitive indicator for assessing the risk of sPTB according to ROC analysis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Singleton pregnancy, transvaginal ultrasound, cervical length, uterocervical angle, spontaneous preterm birth, predictive markers. |
| Subjects: | Obstetrics Gynecology |
| Divisions: | Faculty of Postgraduate Education > Department of Obstetrics, Gynecology and Perinatology FPE |
| Depositing User: | Анастасия Жигар |
| Date Deposited: | 10 Nov 2025 10:27 |
| Last Modified: | 10 Nov 2025 10:27 |
| URI: | http://repo.dma.dp.ua/id/eprint/9629 |
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