Characterization of anti-steatogenic long noncoding RNAsand their epigenetic influence on the development of metabolicfatty liver disease – a systematic review

Abaturov, O.E. and Nikulina, A. (2025) Characterization of anti-steatogenic long noncoding RNAsand their epigenetic influence on the development of metabolicfatty liver disease – a systematic review. European Journal of Clinical and Experimental Medicine = Європейський журнал клінічної та експериментальної медицини, 23 (3). pp. 767-775. ISSN e-2544-1361, p-2544-2406

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Abstract

Introduction and aim. Numerous transcriptomic studies have demonstrated that the development of metabolically associatedfatty liver disease is accompanied by changes in the expression level of long noncoding RNAs (lncRs). The aim: to present a briefdescription of the role of anti-steatogenic lncRs in the epigenetic influence on the development of metabolically associatedfatty liver disease, analyzing the data of modern scientific literature.Material and methods. An analysis of 64 reports over the past 10 years was conducted from the databases PubMed; MEDLINE;EMBASE; Cochrane Systematic Reviews Database; BIOSIS which were selected using the indicated keywords. Quality aspectswere assessed using the adapted Newcastle–Ottawa Scale, PROSPERO CRD420250652980.Analysis of the literature. Hypoexpression of AC012668 – increased representation of miR-380-5p, activation of LRP2; B4GALT1-AS1/lncSHGL, MEG3 – activation of lipogenesis, gluconeogenesis in hepatocytes; FLRL2 – inhibition of BMAL1 and SIRT1;Gm16551 – increased expression of ACC1, SCD1; HR1 – activation of SREBP1c. LncLSTR – activation of cytochrome Cyp8b1 tran-scription; MRAK052686 reduction of FABP7 expression.Conclusion. The formation of hepatosteatosis is supported by a decrease in the expression level of anti-steatogenic lncRs, suchas AC012668, B4GALT1-AS1/lncSHGL, MEG3, FLRL2, Gm16551, lncHR1, lncLSTR, MRAK052686. LncRs overexpression is compen-satory in escalating inflammation, hyperglycemia.

Item Type:	Article
Additional Information:	https://doi.org/10.15584/ejcem.2025.3.16
Uncontrolled Keywords:	anti-steatogenic long noncoding RNAs, epigenetic regulation, metabolically associated fatty liver disease, obesity. антистеатогенні довгі некодувальні РНК, епігенетична регуляція, метаболічно асоційована жирова хвороба печінки, ожиріння.
Subjects:	Endocrinology
Divisions:	Departments > Department of Pediatrics 1 and medical genetics (formerly - Faculty Pediatrics and Medical Genetics)
Depositing User:	Анастасия Жигар
Date Deposited:	09 Mar 2026 11:28
Last Modified:	09 Mar 2026 11:28
URI:	http://repo.dma.dp.ua/id/eprint/9719

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