The changes of matrix metalloproteinase 2, 9 activity and metallothionein level in rat’s brain under cadmium influence

Fomenko, O. and Shiyntum, H. and Shaulska, O. and Ushakova, G. and Shevtsova (2017) The changes of matrix metalloproteinase 2, 9 activity and metallothionein level in rat’s brain under cadmium influence. Матеріали VIІ Конгресу Українського товариства нейронаук, 7 – 11 червня 2017 р. - Київ. p. 33.

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Abstract

The main functions assigned to metallothioneins (MT) are the metal detoxification (heavy metals in particular) like Mercury and Cadmium, metal homeostasis including Cupper and Zinc, anti-oxidation against reactive oxygen species, protection against DNA damage, oxidative stress, cell survival, angiogenesis, apoptosis, as well as increase proliferation, in the body. Matrix metalloproteinases (MMPs) are members of the proteases which share the conserved zinc-binding motif in their catalytic active site. The main goal of work was the investigation of the MMP2 and MMP9 activity and metallothionein level in the brain under cadmium influence at different doses.

Item Type: Article
Additional Information: http://usn.org.ua/data/uploads/USN_Congress_2017.pdf
Uncontrolled Keywords: matrix metalloproteinases, metallothioneins, brain, Cd
Subjects: Biological Chemistry
Divisions: Departments > Department of Biochemistry, Medical and Pharmaceutical Chemistry
Departments > Department of Medical and Biological Physics and Informatics
Depositing User: Елена Шрамко
Date Deposited: 15 Feb 2018 09:09
Last Modified: 15 Feb 2018 14:29
URI: http://repo.dma.dp.ua/id/eprint/2375

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