The effect of SARMs on mitochondrial bioenergetics in skeletal muscles

Rodynskyi, R. and Chernousova, N.M. (2026) The effect of SARMs on mitochondrial bioenergetics in skeletal muscles. In: The Process and Dynamics of the Scientific Path: collection of scientific papers «SCIENTIA» with Proceedings of the X International Scientific and Theoretical Conference, May 1, 2026. French Republic: International Center of Scientific Research, Strasbourg, France, pp. 222-224. ISBN 979-8-89660-279-8

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Abstract

This review summarizes current evidence on the effects of selective androgen receptor modulators (SARMs) on mitochondrial bioenergetics in skeletal muscle. Particular attention is given to the molecular mechanisms underlying SARM-induced activation of the AR–PGC-1α signaling axis, stimulation of mitochondrial biogenesis, enhancement of oxidative phosphorylation, restoration of fatty acid β-oxidation, and attenuation of oxidative stress. Available preclinical and clinical data indicate that SARMs improve mitochondrial function and muscle energy metabolism, supporting their therapeutic potential in sarcopenia, cachexia, and metabolic disorders. However, further large-scale clinical studies are required to establish their long-term efficacy and safety.

Item Type:	Book Section
Uncontrolled Keywords:	selective androgen receptor modulators, SARMs, mitochondrial bioenergetics, skeletal muscle, PGC-1α, oxidative phosphorylation, mitochondrial biogenesis, oxidative stress, sarcopenia, metabolic disorders
Subjects:	Biological Chemistry
Divisions:	Departments > Biochemistry and Medical Chemistry
Depositing User:	Аліна Чеботарьова
Date Deposited:	29 Oct 2026 10:18
Last Modified:	29 Oct 2026 10:18
URI:	http://repo.dma.dp.ua/id/eprint/10340

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