Dovgal, H.V. and Dovgal, M.A. and Zharikov, M.Y. and Rudenko, K.M. and Shevchenko, I.V. and Savochkina, M.V. (2017) Early developmental dynamics of cell surface glycoconjugates in the rat left ventricle myocardium relate to the tissue stereological data. European Applied Sciences, No 1. pp. 17-19.
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Abstract
The purpose of study was to reveal the connection between the dynamics of cellular surface glycoconjugates (detectable by binding plant lectins: PNA, LCA, RCA I, UeA, WGA) and stereological parameters (volume densities of cardiac muscle cells, capillaries and connective tissue) in the left ventricle myocardium of rat heart in early ontogenesis. The weak RCA I binding was observed in the membranes of cardiac myocytes of left ventricle throughout 12-20th days of gestation. There was the moderate reaction with RCA I, LCA and WGA on cellular surface of vascular endothelium, pericardial mesothelium and endocardial luminal cells. LCA and WGA staining revealed the uniform pattern for cardiac muscle cells within the left ventricle myocardium. The weak UeA binding in the cardiac muscle cells appeared after 16th day of gestation in the subepicardial layer of myocardium. PNA binding was not uniform during 14-18th days of gestation in cardiac muscle cells. It was corresponded the stereological differences in regions with the high and low receptors density. During this period, the volume densities of cardiomyocytes and capillaries were higher in areas with strong PNA binding (subepicardial and intramural layers). The volume density of connective tissue was high in areas with weak reaction (subendocardial region). The irregularity in PNA staining of cardiac muscle cells in the left ventricle myocardium disappeared to 20th day of gestation together with а loss of statistical difference in the volume densities of structural components in layers of myocardium.
| Item Type: | Article |
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| Uncontrolled Keywords: | lectins, myocardium, stereological parameters, rat heart |
| Subjects: | Morphology |
| Divisions: | Departments > Department of Pathological Physiology |
| Depositing User: | Елена Шрамко |
| Date Deposited: | 27 Jul 2018 13:31 |
| Last Modified: | 27 Jul 2018 13:31 |
| URI: | http://repo.dma.dp.ua/id/eprint/3047 |
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