Kuruata, O. and Zabida, A. and Sirenko, O. (2018) Serum Matrix Metalloproteinase (Mmp)-2,9 Activity, Galectin-3 and Systemic Inflammation in Patients With Postinfarction Heart Failure with Preserved Ejection Fraction. Медичні перспективи, Т. 23 (№ 1). pp. 89-95. ISSN 2307-0404
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Abstract
The available data suggest that heart failure (HF) after myocardial infarction (MI) is a very frequent event. However, the true prevalence and relevance of diastolic dysfunction after MI remains to be elucidated. Objective: study was designed to evaluate the serum level of MMP 2,9, galactin-3 and C- reactive protein (CRP) in postinfarction heart failure with preserved ejection fraction (HFpEF) patients. Methods: We divided all included patients into two main groups: 1st group- 20 patients with HFpEF and history of myocardial infarction. 2nd group- 18 patients with HFpEF and stable angina. Standard laboratory blood tests, CRP, haematological parameters, lipid profile, glucose, renal and liver function tests were performed for all patients. MMP activity assay and galectin- 3 serum level was detected for all patients.Results: It was established significant differences between study groups in MMP-2, MMP-9 levels. Particularly, patients with HFpEF with MI in anamnesis had significantly higher MMP-2, MMP-9 levels on 21.8 % and 20.7 % respectively. The C-RP and leucocytes levels were significantly higher in 1st group pts. Significant differences in MMP-2, MMP-9 were established in 1st group patients in different age groups (p < 0.05). The MMP 2 level was positively correlated with MMP 9 level (R=0.73, p < 0.05), the MMP 9 level – with age (R=0.68, p < 0.05). There were no significant differences between galectin-3 level in study group. But we estimated significant differences in galectin-3 level between 1st and 2nd subgroups (p < 0.05). Conclusion: Serum MMP-2, MMP-9, CRP and galectin-3 were significantly increased in pts with postinfarction heart failure with preserved ejection fraction compare to pts without myocardial infarction in anamnesis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | postinfarction chronic heart failure, metalloproteinase, galectin-3 |
| Subjects: | Internal diseases |
| Divisions: | Departments > Department of Internal Medicine 2 and phthisiology |
| Depositing User: | Анастасия Жигар |
| Date Deposited: | 24 Sep 2018 10:21 |
| Last Modified: | 24 Sep 2018 10:21 |
| URI: | http://repo.dma.dp.ua/id/eprint/3243 |
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