Abaturov, A.Y. and Vakulenko, L.I. and Kunak, O.V. (2019) Correlation between endothelial dysfunction and left ventricular hypertrophy in children with initial stages chronic kidney disease. Human & Veterinary Medicine International Journal of the Bioflux Society = HVM Bioflux, Vol.11 (Iss. 3). pp. 126-130. ISSN 2066-7663 (Online); I2066-7655(Printed)
|
Text
Correlation between endothelial.pdf Download (353kB) | Preview |
Abstract
Objective: The aim was to study the correlation between inflammation, endothelial dysfunction and left ventricular hypertrophy in children with chronic kidney disease (CKD) stage 2 and 3. Material and methods. The study was conducted on 67 children aged between 6 -17 years. 47 patients had chronic pyelonephritis and CKD stage 2 or 3. The control group consisted of 20 healthy children. All patients underwent routine medical history taking, physical examination, ultrasound imaging and laboratory assessment. Results. Patients were divided into groups depending on the stage of CKD: group 1 included 30 patients with CKD stage 2, group 2 included 17 patients with CKD stage 3. Patients with CKD stage 3 had significantly lower growth rates (p = 0.024), body weight (p = 0.031) and hemoglobin (p = 0.012) compared with the control group. The systolic blood pressure (p = 0.025), the diastolic blood pressure (p = 0.026), and the uric acid (p = 0.019) in this group of patients were statistically higher compared with the control group. Both the patients of group 1 and group 2 had levels of C-reactive protein (CRP) and microalbuminuria significantly higher than those in control group. Patients with CKD stage 3 had an enlarged left ventricle, confirmed by a significant increase of the end-diastolic index (EDI) (p = 0.011) and the end-systolic index (ESI) (p = 0.016) compared with the control group. The left ventricular myocardial mass index (LVMI) was reliably higher in patients with both CKD stage 2 (p = 0.025) and CKD stage 3 (p = 0.007) compared with the control group. Left ventricular hypertrophy was found in 36.7% of the patients with CKD stage 2 and 47.0% of the patients with CKD stage 3. Endothelial dysfunction was detected in 90% of patients with CKD stage 2 and in 100% of patients with CKD stage 3. A significant negative correlation between levels of endotelium-dependent flow-mediated dilation (FMD) and LVMІ (r = -0.49, p = 0.031), CRP (r = -0.76, p <0.001), microalbuminuria (r = -0.65, p <0.001) was found in all patients with CKD. Conclusions. Children with chronic pyelonephritis have early signs of endothelial dysfunction and systemic inflammation, which worsens during mild-to-moderate CKD progression. The presence of the reliable correlations between endothelial dysfunction, systemic inflammation and LVMI suggests the involvement of the endothelium in the development and maintenance of chronic inflammation and the left ventricular hypertrophy formation.
| Item Type: | Article |
|---|---|
| Additional Information: | Citation Abaturov AY, Vakulenko LI, Kunak OV. Correlation between endothelial dysfunction and left ventricular hypertrophy in children with initial stages chronic kidney disease. HVM Bioflux 2019;11(3):126-130. |
| Uncontrolled Keywords: | chronic pyelonephritis, children, chronic kidney disease, endothelial dysfunction, left ventricular hypertrophy |
| Subjects: | Pediatrics |
| Divisions: | Departments > Department of Pediatrics 1 and medical genetics (formerly - Faculty Pediatrics and Medical Genetics) Departments > Department of Pediatrics 2 (formerly - hospital pediatrics 1) |
| Depositing User: | Елена Шрамко |
| Date Deposited: | 27 Aug 2019 13:08 |
| Last Modified: | 30 Aug 2019 08:36 |
| URI: | http://repo.dma.dp.ua/id/eprint/4251 |
Actions (login required)
 |
View Item |
