Больбот, Ю.К. and Годяцька, К.К. and Бордій, Т.А. (2018) Значення дефіциту вітаміну D у формуванні повторних епізодів бронхообструктивного синдрому у дітей раннього віку. Проблеми клінічної педіатрії, 1 (39). pp. 17-27. ISSN 1998-6475
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Abstract
Recurrent course of broncho-obstructive syndrome (BOS) on the background of acute respiratory viral infections (ARVI) in young children is an actual problem of pediatric practice. Such predisposition may be supported by numerous factors including low levels of vitamin D (VD). Thus, the aim of the study was to increase the effectiveness of treatment of children who are predisposed to recurrent episodes of BOS by correcting VD deficiency on the basis of studying its effect on the clinical course of the disease, biochemical and immunological parameters. 120 patients aged 6 months to 3 years with a clinical diagnosis of acute obstructive bronchitis were examined. I group included 60 children with episodic BOS (less than three episodes), group II - 60 children with recurrent BOS (3 or more episodes). Clinical examination, evaluation of concentration of 25-hydroxyvitamin D (25 (OH) D), interferon gamma (IFN-γ), interleukin (IL)-4, total calcium (Ca) and magnesium (Mg) in serum were performed. 30 clinically healthy children are considered as a control group. It was established that children of group II had VD deficiency unlike patients of group I who had a sufficient serum level of 25 (OH) D (13.68 (7.96; 19.51) ng/ml and 33.0 (28.19, 41.97) ng/ml respectively, p<0.001). The most important factor determining the development of insufficiency or deficiency of VD was the low level of its supplementation (RR=7,383; 95% CI 2,448-22,261; p <0,001). The groups did not differ from each other in their content of IFN-γ in the blood (21.08 (8.57; 37.03) pg / ml in group II versus 22.69 (8.98; 41.44) pg / ml in group I, p=0.381). The level of IL-4 in children in group II was slightly lower than in patients in group I (2.26 (2.05; 2.41) and 2.37 (2.12; 2.64) respectively, p=0.012). The daily administration of vitamin D3 at a dose of 1000 IU during the year contributed to an increase the level of 25 (OH) D in serum (13.93 (9.60; 20.5) ng / ml at the start of the study versus 25.11 (12.14; 42.47) ng / ml after supplementation of vitamin D3, p=0.002). In addition, the frequency of recurrent episodes of BOS during the year on background of supplementation of vitamin D3 decreased by 20%. Consequently, recurrent BOS episodes on the background of ARVI are associated with a low level of VD. The use of vitamin D3 at a dose of 1000 IU per day for one year in young children who are predisposed to recurrent BOS can reduce both the frequency and severity of its episodes, as well as improve serum levels of 25 (OH) D.
| Item Type: | Article |
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| Uncontrolled Keywords: | бронхообструктивний синдром; діти раннього віку; вітамін D; дефіцит; корекція; цитокіни; broncho-obstructive syndrome; young children; vitamin D; deficiency; correction; cytokines |
| Subjects: | Pediatrics |
| Divisions: | Departments > Department of Pediatrics 3 and Neonatology (formerly - Hospital Pediatrics 2 and Neonatology) |
| Depositing User: | Елена Шрамко |
| Date Deposited: | 04 Dec 2019 09:44 |
| Last Modified: | 04 Dec 2019 09:44 |
| URI: | http://repo.dma.dp.ua/id/eprint/4624 |
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