Дука, Р.В. and Кошарний, В.В. and Абдул-Огли, Л.В. and Кушнарьова, К.А. (2018) Морфометричні зміни серця при ожирінні та після його хірургічного лікування. Вісник проблем біології і медицини=Bulletin of problems biology and medicine, В. 3 (145). pp. 282-284. ISSN 2077-4214 (Print), 2523-4110 (Online)
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Abstract
Ожирение провоцирует ускорение развития факторов, которые составляют сердечно-сосудистый риск в целом. Проблема избыточного веса – бич современности. Ожирение диагностируется довольно часто. Поэтому консервативный подход не всегда рационален. Хирургические методы лечения ожирения как никогда актуальны. Целью работы было установить морфометрические изменения в сердце при ожирении и после хирургического лечения. В результате наших исследований мы наблюдали изменения в стенке сердца на всех уровнях организации. На 30 сутки от начала эксперимента проводили комплексное исследование сердца с помощью морфометрических исследований на всех уровнях структурной организации. После удаления сердца из грудной полости его взвешивали, масса в среднем равна: 2,10 ± 0,025 г. Индекс отношения массы сердца к весу крысы равен 0,54. При ожирении преобладает шарообразная форма сердца, на эту форму перепадает 85% от всех форм сердца. При ожирении вес сердца увеличивается в 3,44 раза, при резекции желудка его вес уменьшается в 1,75 раза. Площадь поперечного сечения левого желудочка, после резекции желудка, уменьшилась на 20 мм2, правого желудочка на 11 мм2. Все эти патологические изменения наблюдаемые подтверждают положительные изменения при резекции желудка на сердечно-сосудистую систему в частности на морфометрические показатели сердца. Obesity provokes the acceleration of the development of factors that make up the cardiovascular risk in general. Obesity and arterial hypertension potentiate one another in relation to the development of an adverse effect on the structure and function of the heart, increases the level of pre- and post-load on the heart, especially in people with severe and prolonged (> 15 years) obesity; the risk of the formation of GMSH from 5.5% in people with normal body weight up to 29.9% in obese people is increasing. When joining the obesity of hypertension, the risk of hypertrophy of the heart increases more than 4 times. The problem of overweight is the scourge of our time. Obesity is diagnosed quite often. Therefore, the conservative approach is not always rational. Surgical treatments for obesity are never more relevant than ever. Purpose. To establish morphometric changes in the heart during obesity and after surgical treatment. Object and methods. We were modeling obesity according to the standard method of high-calorie nutrition, within a month. The weight of rats was 380-400 g. Surgical treatment was performed by resection of the stomach in large curvature. Results and discussion. As a result of our research, we observed changes in the heart wall at all levels of the organization. At 30 days from the beginning of the experiment, a comprehensive heart study was conducted using morphometric studies at all levels of the structural organization. After removing the heart from the thoracic cavity, it was weighed, the mass on average equaled: 2.10 ± 0.025 g. The index of the ratio of the mass of the heart to the weight of the rat was 0.54. To determine the shape of the heart of rats, we calculated the index of the ratio of the width of the heart to its length (F). In 85% of cases, the obesity of the rats’ heart rats was globular, the index (F) amounted to an average of 86%, with an ellipsoidal pattern of 9%, an index of more than 65%. Cone-shaped form was observed in 6% of cases. At 30 days from the beginning of the experiment, the analysis of the thickness of the wall of the heart at various levels showed that the highest rates were in the middle third of the heart, it was observed in both the right and left ventricles of the heart. Analyzing the thickness of the ventricular wall, it was found that changes occurred unevenly at different levels, and the greatest changes in the indicators compared with the control occurred in the middle third. In the interventricular lining, the average third changed more. The thickness of the anterior wall of the left ventricle was 3.8 ± 0.1 mm, the back wall was 3.9 ± 0.11 mm, the side wall 3.1 ± 0.08 mm, the interventricular membrane 3.6 ± 0.09 mm in the right ventricle the thickness of the front wall is 1,26 ± 0,04 mm, the back wall 1,56 ± 0,06 mm. The cross-sectional area of the right and left ventricles of the rat’s heart was equal to the left ventricle of 535.0 ± 4.2 mm2, in the right ventricle 125.0 ± 3.1 mm2.
| Item Type: | Article |
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| Additional Information: | DOI 10.29254/2077-4214-2018-3-145-282-284 |
| Uncontrolled Keywords: | ожиріння, серце, морфометрія. ожирение, сердце, морфометрия. obesity, heart, morphometry. |
| Subjects: | Morphology Obesity Surgery |
| Divisions: | Departments > Department of human anatomy, clinical anatomy and operative surgery Departments > Department of Human Anatomy Departments > Department of Surgery №1 |
| Depositing User: | Анастасия Жигар |
| Date Deposited: | 21 Apr 2020 17:50 |
| Last Modified: | 21 Apr 2020 17:50 |
| URI: | http://repo.dma.dp.ua/id/eprint/5253 |
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