The Role of Phagocytosis Deficiency in Adults with Non-Cystic Fibrosis Bronchiectasis

Suska, K. and Gashynova, K. and Dmytrychenko, V. (2020) The Role of Phagocytosis Deficiency in Adults with Non-Cystic Fibrosis Bronchiectasis. American Journal of Respiratory and Critical Care Medicine, 201. A5415. ISSN 1073-449X (Print); 1535-4970 (Online)

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Abstract

RATIONALE. Bronchiectasis (B) is a chronic respiratory disease accompanied by recurrent respiratory tract infection.The measurement of total serum IgG, IgA and IgM is recommended as a routine “bundle” of tests at diagnosis to identifypossible underlying causes of B by the “European Respiratory Society guidelines for the management of adultbronchiectasis”. The study aimed to identify the prevalence of immunodeficiency associated with a decrease in the totalimmunoglobulins levels and to determine the significance of phagocytosis in the development of chronic colonization ofthe respiratory tract in patients (pts) with B. METHODS. 55 pts with confirmed B by HRCT were included in the studyduring the stable phase. Serum IgA, IgM, IgG were measured by immunoturbidimetry method. Phagocyte number andphagocytic activity were measured by flow cytometry. Microbiological detection of sputum samples were conducted byconventional bacteriological methods. The methods of descriptive and non-parametric statistics were used to process theresults. RESULTS. Depending on the presence of sputum colonization by pathogens, the pts were divided in two groups:G1 - with sputum colonization (n=37) and G2 - without detected pathogens in sputum culture (n=18). There were nodifferences in groups by gender and age (p=0.33 and p=0.05 respectively). The levels of total serum IgA, IgM, IgG weremeasured in all pts and we did not detect a decrease in the level of any of the immunoglobulins. Then we determined thephagocyte number and phagocytic activity levels in eight pts from G1 and in six pts from G2. Results are presented in the table. CONCLUSIONS. Among the examined patients there were no cases of immunodeficiencies associated with a decreaseof total serum immunoglobulins and their levels did not statistically differ in the groups with and without sputumcolonization with pathogens. All patients with B and chronic sputum colonization have a reduced number of phagocytes,and the majority of them have low phagocytic activity. Following results obtained, a routine study of the state of innateimmunity is recommended for all patients with B to predict the likelihood of chronic sputum colonization and for furthercorrection of therapeutic tactics. K. Suska, K. Gashynova, V. Dmytrychenko; D

Item Type:	Article
Uncontrolled Keywords:	bronchiectasis, phagocytosis, humoral immunity
Subjects:	Pulmonology
Divisions:	Departments > Department of occupational diseases, clinical immunology and clinical pharmacology
Depositing User:	Елена Шрамко
Date Deposited:	07 Sep 2020 13:44
Last Modified:	07 Sep 2020 13:44
URI:	http://repo.dma.dp.ua/id/eprint/5683

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