Results from the Survey of Antibiotic Resistance (SOAR) 2011–13 in Ukraine

Feshchenko, Y. and Dzyublik, A. and Pertseva, T. and Bratus, E. and Dzyublik, Y. and Gladka, G. and Morrissey, I. and Torumkuney, D. (2016) Results from the Survey of Antibiotic Resistance (SOAR) 2011–13 in Ukraine. Journal of Antimicrobial Chemotherapy, 71 (1). i63-i69. ISSN 0305-7453 (Print), 1460-2091 (Online)

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Abstract

Objectives: To determine the antibiotic susceptibility of respiratory isolates of Streptococcus pneumoniae and Haemophilus influenzae collected in 2011–13 from Ukraine. Methods: MICs were determined by CLSI broth microdilution and susceptibility was assessed using CLSI, EUCAST and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. Results: A total of 134 isolates of S. pneumoniae and 67 of H. influenzae were collected from eight sites in Ukraine. Overall, 87.3% of S. pneumoniae were penicillin susceptible by CLSI oral breakpoints and 99.3% by CLSI iv breakpoints. Susceptibility to amoxicillin/clavulanic acid (amoxicillin), ceftriaxone and levofloxacin was 100% by CLSI and PK/PD breakpoints. Cephalosporin and macrolide susceptibility was ≥95.5% and 88.1%, respectively using CLSI breakpoints. Trimethoprim/sulfamethoxazole was essentially inactive against pneumococci. Of the 67 H. influenzae tested, 4.5% were b-lactamase positive and all H. influenzae were fully susceptible to amoxicillin/ clavulanic acid, ceftriaxone, ciprofloxacin, cefixime and levofloxacin (all breakpoints). Cefuroxime susceptibility was 100% by CLSI but 73.1% by EUCAST and PK/PD breakpoints. A discrepancy was found in macrolide susceptibility between CLSI (100% susceptible), EUCAST (22%–43% susceptible) and PK/PD (0%–22% susceptible) breakpoints. Trimethoprim/sulfamethoxazole was poorly active (59.7% susceptible). Conclusions: Generally, antibiotic resistance was low in respiratory pathogens from Ukraine. However, only amoxicillin/clavulanic acid (amoxicillin), ceftriaxone and levofloxacin were fully active against both species. Trimethoprim/sulfamethoxazole was the least active, particularly against S. pneumoniae. Some susceptibility differences were apparent between CLSI, EUCAST and PK/PD breakpoints, especially with macrolides against H. influenzae. These data suggest that further efforts are required to harmonize these international breakpoints. Future studies are warranted to monitor continued low resistance levels in Ukraine compared with other parts of Eastern Europe.

Item Type:	Article
Additional Information:	Cite Y. Feshchenko, A. Dzyublik, T. Pertseva, E. Bratus, Y. Dzyublik, G. Gladka, I. Morrissey, D. Torumkuney, Results from the Survey of Antibiotic Resistance (SOAR) 2011–13 in Ukraine, Journal of Antimicrobial Chemotherapy, Volume 71, Issue suppl_1, May 2016, Pages i63–i69, https://doi.org/10.1093/jac/dkw068 Идентификационный номер: WOS:000376292100006 Идентификатор PubMed: 27048583
Uncontrolled Keywords:	COMMUNITY-ACQUIRED PNEUMONIA; STREPTOCOCCUS-PNEUMONIAE; ANTIMICROBIAL RESISTANCE; EPIDEMIOLOGY; EUROPE
Subjects:	Pharmacognosy Infectious diseases Microbiology
Divisions:	Departments > Department of Internal Medicine 1 (formerly - Faculty Therapy and Endocrinology)
Depositing User:	Елена Шрамко
Date Deposited:	14 May 2021 14:18
Last Modified:	14 May 2021 14:18
URI:	http://repo.dma.dp.ua/id/eprint/6504

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