Clinical, Anamnestic and Laboratory Predictors of Preterm Premature Rupture of Membranes in Pregnant Women

Dubossarska, Yu.O. and Puzii, Ye.O. (2021) Clinical, Anamnestic and Laboratory Predictors of Preterm Premature Rupture of Membranes in Pregnant Women. Azerbaijan Medical Journal (№ 4). pp. 12-18. ISSN 0005-2523

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Abstract

A study was conducted to assess of the clinical status of pregnant women with preterm premature rupture of membranes (pPROM) and to determine the role of 25-OH vitamin D and the level of expression of antimicrobial peptides (beta-2-defensins) as prognostic markers of pPROM. A study of two groups of women (pPROM at 23-36 weeks of gestation (main group) and with intact fetal membranes, who had a normal vaginal delivery (control group)) was found that pPROM is significantly (p <0.05) more common in the presence of such risk factors as: 2 or more abortions in the anamnesis, chronic pyelonephritis, asymptomatic bacteriuria, the threatened abortion. The most common complication of pPROM was retained placenta after vaginal delivery. The average content of 25-OH vitamin D in the blood of pregnant women with pPROM was 26.32±0.87 pg/ml vs. 52.9±2.37 pg/ml in the control group, and the expression level of beta-2-defensins was 78.03±1.74 pg/ml vs. 107.42±2.56 pg/ml in the control group (p<0.001). According to the authors, the established clinical, anamnestic and laboratory features of pregnancy and labor in pregnant women with pPROM may become the basis for the creation of algorithms for early diagnosis and prediction of pPROM and premature birth.

Item Type:	Article
Additional Information:	DOI: 10.34921/amj.2021.4.002
Uncontrolled Keywords:	preterm birth, preterm premature rupture of membranes, 25-OH vitamin D, beta-2-defensins.
Subjects:	Obstetrics Gynecology
Divisions:	Faculty of Postgraduate Education > Department of Obstetrics, Gynecology and Perinatology FPE
Depositing User:	Анастасия Жигар
Date Deposited:	16 Feb 2022 13:31
Last Modified:	16 Feb 2022 13:31
URI:	http://repo.dma.dp.ua/id/eprint/7338

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