Testicular changes under the influence of cadmium in combination with metal succinates: modern view of the problem (literature review)

Gruzd, Vlada and Frolova, Hanna and Alekseyenko, Zoya (2021) Testicular changes under the influence of cadmium in combination with metal succinates: modern view of the problem (literature review). Modern Science — Moderní věda (№ 3). pp. 108-114. ISSN 2336-498X

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Abstract

Now an increasing number of studies indicate that male fertility, primarily spermatogenesis and ejaculate parameters, is adversely affected by an increase in environmental pollution with hazardous technogenic toxicants, among which heavy metals, in particular, cadmium, occupy a priority position. Continuous sources of cadmium contamination are associated with industrial production, nickel-cadmium batteries, pigments, plastics and other synhetic products. Most research scientists believe that cadmium-associated disorders of the functional activity of the hypothalamic-pituitary-gonadal system in men are manifested by a violation of both hormonal regulation of the reproductive system and the functioning of the epitheliospermatogenic layer of the seminal glands, causing pathological changes in both the quantitative and qualitative composition of sperm. Cadmium induces lipid peroxidation and reduces the activity of antioxidant enzymes, causes degenerative and destructive changes in the spermatogenic epithelium, abnormal changes in the morphological structure of sustentocytes, thereby creating favorable conditions for disturbances in the morpho-functional organization of the bloodtesticular barrier and spermatogenesis. Cadmium disrupts the development and function of interstitial endocrinocytes, induces damage to their genome, enhances apoptosis of Leydig cells and causes degradation of the seminiferous tubules, and weakens the expression of genes associated with the production of male sex hormone.

Item Type:	Article
Uncontrolled Keywords:	cadmium, cadmium-induced testicular changes, testosterone,reactive oxygen species, male infertility, spermatogenesis.
Subjects:	Anatomy
Divisions:	Departments > Department of human anatomy, clinical anatomy and operative surgery
Depositing User:	Елена Шрамко
Date Deposited:	26 Apr 2022 08:38
Last Modified:	26 Apr 2022 08:38
URI:	http://repo.dma.dp.ua/id/eprint/7444

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