Etiology and efficacy of anti-microbial treatment for community-acquired pneumonia in adults requiring hospital admission in Ukraine

Kaidashev, I. and Lavrenko, A. and Baranovskaya, T. and Blazhko, V. and Digtiar, N. and Dziublyk, O. and Gerasimenko, N. and Kryvetsky, V. and Kuryk, L. and Rodionova, V and Feshchenko, Y. (2022) Etiology and efficacy of anti-microbial treatment for community-acquired pneumonia in adults requiring hospital admission in Ukraine. Acta Biomedica (ActaBiomed), Vol.93 (N. 2). e2022238. ISSN 0392-4203 (Print), 2531-6745 (Online)

Text abm-13137.pdf Download (136kB)

Abstract

Background and aim: Empiric therapy of community-acquired pneumonia (CAP) remains the standard care and guidelines are mostly based on published data from the United States or Europe. In this study, we determined the bacterial etiology of CAP and evaluated the clinical outcomes under antimicrobial treatment of CAP in Ukraine. Methods: A total of 98 adult subjects with CAP and PORT risk II-IV were recruited for the study. The sputum diagnostic samples were obtained from all patients for causative pathogen identification. Subjects were randomly assigned in a 1:1 ratio to receive delafloxacin 300 mg (n=51) or moxifloxacin 400 mg (n=47) with a blinding placebo. The switch to oral treatment was after a minimum of 6 IV doses according to clinical criteria. The total duration of antibacterial treatment was 5-10 days. In vitro susceptibility of pathogens to delafloxacin and other comparator antibiotics was determined. Results: The most frequently isolated pathogens in adults with CAP were S. pneumoniae – 19.5%, M. pneumoniae – 15.3%, H. influenzae – 13.2%, S. aureus – 10.5%, K. pneumoniae – 10.1%, and H. parainfluenzae – 6.4%. All isolates of S. pneumoniae, S. aureus, M. pneumoniae had sufficient susceptibility to appropriate antibiotics. 9.0% of H. influenzae strains were susceptible to azithromycin. 94.8 % of patients had a successful clinical response to delafloxacin at the end of treatment and 93.9 % – at test-of-cure. Conclusions: In Ukraine, the major bacterial agents that induced CAP in adults were S. pneumoniae, M. pneumoniae, H. influenzae, S. aureus, K. pneumoniae, H. parainfluenzae, E. cloacae, L. pneumophila. Delafloxacin is a promising effective antibiotic for monotherapy of CAP in adults and could be used in cases of antimicrobial-resistant strains. (www.actabiomedica.it)

Item Type:	Article
Additional Information:	How to Cite Kaidashev, I., A. Lavrenko, T. Baranovskaya, V. Blazhko, N. Digtiar, O. Dziublyk, N. Gerasymenko, L. Iashyna, V. Kryvetskyi, L. Kuryk, V. Rodionova, R. Stets, I. Vyshnyvetskyy, and Y. Feshchenko. “Etiology and Efficacy of Anti-Microbial Treatment for Community-Acquired Pneumonia in Adults Requiring Hospital Admission in Ukraine”. Acta Biomedica Atenei Parmensis, vol. 93, no. 2, May 2022, p. e2022238, doi:10.23750/abm.v93i2.13137.
Uncontrolled Keywords:	antibiotics, community-acquired pneumonia, delafloxacin, empiric antimicrobial therapy, moxifloxacin
Subjects:	Pulmonology
Divisions:	Departments > Department of occupational diseases, clinical immunology and clinical pharmacology
Depositing User:	Елена Шрамко
Date Deposited:	26 May 2022 10:38
Last Modified:	26 May 2022 10:45
URI:	http://repo.dma.dp.ua/id/eprint/7557

Actions (login required)

View Item