Filippova, A.Yu. and Löhr, M. and Kryvoshei, V.V. (2022) Blood lipid spectrum and elastic properties of arteries in patients with chronic pancreatitis in combination with arterial hypertension. Медичні перспективи = Medicni perspektivi (Medical perspectives), 27 (1). pp. 42-49. ISSN 2307-0404 (print), 2786-4804 (online)
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Abstract
110 patients aged 45-65 years with chronic pancreatitis were examined. The first group consisted of patients with a combined course of chronic pancreatitis with arterial hypertension; the second group - patients with chronic pancreatitis without concomitant hypertension. All patients were examined for total cholesterol, triglycerides, high-density lipoprotein cholesterol, lowdensity lipoprotein cholesterol, and very low-density lipoprotein cholesterol. Arterial stiffness was determined by the pulse wave velocity. It was found that patients of the 1st group had significantly higher levels of triglycerides (37.2%), low-density lipoprotein cholesterol (13%), total cholesterol (25%), atherogenic ratio (19.6%) and significantly lower levels of high-density lipoprotein cholesterol (15.4%). Correlations between age and the level of atherogenic ratio, lowdensity lipoprotein cholesterol were established – r=0.35; p<0.01; r=0.37; p<0.01, respectively. The duration of chronic pancreatitis positively correlated with the level of triglycerides, low-density lipoprotein cholesterol – r=0.43; p<0.01; r=0.34; p<0.01, respectively. The level of brachial artery augmentation index was significantly lower by 43% in patients with chronic pancreatitis in combination with arterial hypertension, while the aortic augmentation index was significantly higher by 37.6% (p<0.01). It was found that patients of the 1st group had a significantly higher pulse wave velocity in the carotid-femoral segment compared to the 2nd group – by 7.5% (p<0.01). Significant correlations have been established between the brachial artery augmentation index and age, total cholesterol, atherogenic ratio, high and low density lipoprotein cholesterol, triglycerides, cardiovascular risk level by the SCORE scale in patients with a combined course of chronic pancreatitis with arterial hypertension. Conclusions. Patients with the combination of chronic pancreatitis and hypertension had significantly higher levels of triglycerides, low-density lipoprotein cholesterol and total cholesterol. Changes in the elastic properties of arteries in patients with chronic pancreatitis with comorbid hypertension were characterized by an increase in the augmentation index and the pulse wave velocity in the carotid-femoral segmen
| Item Type: | Article |
|---|---|
| Additional Information: | DOI: 10.26641/2307-0404.2022.1.254320 |
| Uncontrolled Keywords: | blood lipid spectrum, elastic properties of arteries, chronic pancreatitis, arterial hypertension; ліпідний спектр крові, пружноеластичні властивості артерій, хронічний панкреатит, артеріальна гіпертензія; липидный спектр крови, упругоэластические свойства артерий, хронический панкреатит, артериальная гипертензи. |
| Subjects: | Internal Medicine Gastroenterology |
| Divisions: | Departments > Department of Internal Medicine 2 and phthisiology University periodicals > Medical perspectives |
| Depositing User: | Ирина Медведева |
| Date Deposited: | 16 Nov 2022 09:30 |
| Last Modified: | 16 Nov 2022 09:30 |
| URI: | http://repo.dma.dp.ua/id/eprint/7938 |
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