Про-та протизапальні ефекти простагландинів та лейкотрієнів, що до крові та нирки при експериментальному пієлонефриті, ускладненому цукровим діабетом з оцінкою фармакокорекції

Борисов, С.О. and Костєв, Ф.І. and Борисов, О.В. (2021) Про-та протизапальні ефекти простагландинів та лейкотрієнів, що до крові та нирки при експериментальному пієлонефриті, ускладненому цукровим діабетом з оцінкою фармакокорекції. Урологія, 25 (4). pp. 265-274. ISSN 2307-5279

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Abstract

This study is experimental and clinical, performed on laboratory rats and is dedicated to the purpose of determining the level of prostaglandin E-2 and leukotriene B-4 in the blood plasma and kidney tissue of animals with acute pyelonephritis against the background of a concomitant hyperglycemic state for monitoring the development and course of the inflammatory process and assessing the effectiveness drug influence. The renal tissue contains a significant amount of prostaglandins and is actively involved in their synthesis and metabolism, regulating the inflammatory reactions and tone of the upper urinary tract, maintaining a normal balance between different groups of PGs, which have multidirectional physiological effects. It was found that in acute pyelonephritis in rats, a significant increase in the level of prostaglandin E2 in blood plasma by 106.4% and kidney tissue by 48.9%, and leukotriene B4 in blood plasma by 54.8% and in kidney by 27.5% was revealed. compared to the norm. It should be noted that the use of etiotropic-pathogenetic drug action contributed to a significant decrease in the levels of PGE2 and LV4 in the blood plasma and in the kidney tissue of rats with reproductive acute pyelonephritis and diabetes mellitus, which indicates the effectiveness of the proposed drug effect on the course of the infectious and inflammatory process and prevention of the development of severe renal complications due to concomitant hyperglycemic conditions.

Item Type:	Article
Additional Information:	DOI 10.26641/2307-5279.25.4.2021.253248
Uncontrolled Keywords:	пієлонефрит, гіперглікемія, дослідження, перебіг, плазма крові, тканина нирок, цитокін, лейкотрієни, медикаментозний вплив
Subjects:	Urology Diabetes Experimental medicine
Divisions:	University periodicals > Урологія
Depositing User:	Аліна Чеботарьова
Date Deposited:	18 Nov 2022 12:08
Last Modified:	18 Nov 2022 12:08
URI:	http://repo.dma.dp.ua/id/eprint/7945

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