Recurrent viral-induced wheezing in young children – the protective role of vitamin D supplementation

Hodiatska, Kateryna and Bolbot, Yurii and Shvaratska, Olha and Bordii, Tina and Alifanova, Svitlana (2022) Recurrent viral-induced wheezing in young children – the protective role of vitamin D supplementation. Pediatria Polska – Polish Journal of Paediatrics, 97 (3). pp. 242-248. ISSN 2300-8660 (Online), 0031-3939 (Print)

Text Годяцька, Больбот, Шварацька, Бордій, Аліфанова.pdf Download (188kB)

Abstract

Introduction: Vitamin D (VD) deficiency has been linked to recurrent respiratory infections in recent years. However, the impact of VD supplementation on recurrent viral-induced wheezing in early childhood remains unclear. Thus, we aimed to investigate the effect of daily VD supplementation on recurrent viral-induced wheezing episodes in young children. Material and methods: This observational prospective cohort study involved 60 patients with recurrent viralinduced wheezing and 30 healthy children, all aged 6 months to 3 years. Patients with recurrent wheezing were assigned to receive 1000 IU of vitamin D3 daily (VD group, n = 30) or no VD supplements (control group, n = 30) for a total of 12 months. Serum 25-hydroxyvitamin D (25(OH)D) concentrations were measured in all study subjects at baseline and at the 12-month follow-up visit using electrochemiluminescence immunoassay. Results: VD deficiency was detected in 75% of children with recurrent wheezing. VD levels below 20 ng/ ml were linked to 4-fold increased odds of developing recurrent wheezing (OR = 4.35; 95% CI: 2.75-6.86; р < 0.001). At 12 months, the median number of wheezing episodes in the control group was twice as much than the VD group (2.0 [1.0; 3.0] vs. 1.0 [0.0; 2.0], respectively, p < 0.001). VD supplementation increased the median serum 25(OH)D concentration to 25.11 (12.14; 42.47) ng/ml. The vast majority (71%) of VD-insufficient recurrent wheezers attained sufficiency over 12 months. Among VD-deficient children, 54.5% remained deficient, 31.9% achieved insufficiency, and 13.6% achieved sufficient VD status. Conclusions: VD supplementation of 1000 IU/day reduces the incidence of recurrent early wheezing. The supplemental dose of vitamin D3 was not optimal to achieve sufficient VD status in patients with baseline VD deficiency.

Item Type:	Article
Additional Information:	Hodiatska K, Bolbot Y, Shvaratska O, Alifanova S, Bordii T. Recurrent viral-induced wheezing in young children – the protective role of vitamin D supplementation. Pediatria Polska - Polish Journal of Paediatrics. 2022;97(3):242-248. doi:10.5114/polp.2022.120143. 1. Hodiatska K, Bolbot Y, Shvaratska O, Bordii T, Alifanova S. Recurrent viral-induced wheezing in young children - the protective role of vitamin D supplementation. Pediatr Pol [Internet]. 2022;97(3):242-8. Available from: www.scopus.com
Uncontrolled Keywords:	vitamin D, supplementation, young children, wheezing.
Subjects:	Pediatrics
Divisions:	Departments > Department of Pediatrics 3 and Neonatology (formerly - Hospital Pediatrics 2 and Neonatology)
Depositing User:	Елена Шрамко
Date Deposited:	09 Jan 2023 12:49
Last Modified:	09 Jan 2023 12:51
URI:	http://repo.dma.dp.ua/id/eprint/8056

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