Charactirestics of vitamin d level in patients with atopic dermatitis

Garibeh, E. and Bondar, S.А. and Tokarchuk, N.I. and Vyzgha, Y.V. (2022) Charactirestics of vitamin d level in patients with atopic dermatitis. Медичні перспективи = Medicni perspektivi (Medical perspectives) (3). pp. 108-114. ISSN 2307-0404 (print), 2786-4804 (online)

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Abstract

. The peculiarity of the skin is that it acts not only as a place of synthesis of vitamin D, but also as an organ targeted for its biologically active form. The aim of our study was to analyze the level of vitamin D inpatients with atopic dermatitis. There were examined 48 people aged between 18 to 55 years; they are residents of Vinnytsia and Vinnytsia region. Serum levels of vitamin D, total IgE and eosinophilic cationic protein (ECP) were determined in the subjects. The average level of vitamin D in the serum of patients with atopic dermatitis was 19.2 [11.3- 25.4] ng/ml, which corresponded to a deficiency. Among those surveyed, vitamin D deficiency was found in 68.4±4.7% (n=26) while vitamin D insufficiency in 31.6±4.5% (n=12). The severe course of the disease prevailed among patients aged 18-40 years (63.33±8.79) % more than in the age group of 41 years and older, (36.67±8.8%, p<0.05; OR=2.98, S=0.53, 95% SI:1.04-8.52). The proportion of people with vitamin D deficiency and moderate severity of atopic dermatitis was 62.5% (n=10) with a median level of 14 [8.3–19] ng/ml, and patients with severe atopic dermatitis made up 90.9% (n=20) (χ²=4.6; p=0.023), in which the median level of vitamin D was 14 [8.3-19] ng/ml. Serum vitamin D levels were in the zone of deficiency in patients with moderate and severe atopic dermatitis. Vitamin D deficiency was significantly more common in the group of patients with elevated levels of allergic inflammation markers. A positive correlation of medium strength between the level of vitamin D and ECP in the serum of patients with atopic dermatitis (rs=0.53, p<0.001), was revealed

Item Type:	Article
Additional Information:	DOI: 10.26641/2307-0404.2022.3.265954
Uncontrolled Keywords:	atopic dermatitis, vitamin D; атопічний дерматит, вітамін Д
Subjects:	Dermatology and Venereal Diseases
Divisions:	University periodicals > Medical perspectives
Depositing User:	Ирина Медведева
Date Deposited:	30 Mar 2023 09:15
Last Modified:	30 Mar 2023 09:15
URI:	http://repo.dma.dp.ua/id/eprint/8271

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