The influence of cadmium chloride on the histostructure of the ovaries of pregnant and non- pregnant rats

Kolosova, I.I. (2024) The influence of cadmium chloride on the histostructure of the ovaries of pregnant and non- pregnant rats. Вісник проблем біології і медицини = Bulletin of problems biology and medicine, (172) (1). pp. 401-411. ISSN 2077-4214 (Print), 2523-4110 (Online)

Text THE INFLUENCE OF CADMIUM CHLORIDE ON THE HISTOSTRUCTURE .....pdf Download (1MB)

Abstract

Cadmium compounds have a negative impact on reproductive health and can lead to the formation of diseases during the prenatal period. The problems of female infertility require in-depth knowledge of the structure, blood supply and functioning of the ovaries both in normal conditions and under the influence of toxicants. Our study aimed to experimentally determine the potential gonadotoxic effect of cadmium chloride (at a dose of 1.0 mg/kg). For the study, 40 female Wistar rats were used, divided into 2 groups (control and experimental) depending on the solutions received. In each group, females were divided in half: pregnant and non-pregnant. The test substances were administered to the females intragastrically through a gavage tube once a day, at the same time throughout pregnancy, and on day 13, the animals were surgically killed, and the body was dissected, removing the ovaries for histological examination. In the control and experimental groups, the ovaries of female rats had a structure typical of other mammals, but in the experimental group exposed to cadmium chloride, changes in the histological structure of the ovaries of pregnant and non-pregnant females were found, namely thickening of the protein membrane, decreased follicle growth, increased number of antral and atretic follicles, irregular follicle borders, reduced, damaged, fragmented/absent ovocytes, degeneration of follicular granulosa cells; disorganisation, swelling and decreased number of corpus luteum, as well as increased number of fibrils in the connective tissue, hyperaemia of capillaries and venous vessels, thinning of blood vessel walls, and edema

Item Type:	Article
Additional Information:	DOI: 10.29254/2077-4214-2021-1-159-138-143
Uncontrolled Keywords:	reproductive system, ovaries, cadmium chloride, experiment, gonadotoxicity
Subjects:	Medical Biology
Divisions:	Departments > Department of Medical Biology, Botany and Pharmacognosy
Depositing User:	Аліна Чеботарьова
Date Deposited:	02 Dec 2024 12:51
Last Modified:	02 Dec 2024 12:51
URI:	http://repo.dma.dp.ua/id/eprint/9213

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