Influence the octenidine dihydrochloride on the tissues of knee joints of immature laboratory rats

Digtyar, V.A. and Baibakov, V.M. and Lukianenko, D.M. and Zharikov, M.Y. and Zharikova, V.M. (2017) Influence the octenidine dihydrochloride on the tissues of knee joints of immature laboratory rats. Web of Scholar, Vol. 1 (9 (18)). pp. 53-56. ISSN 2518-167X (print), 2518-1688 (Online)


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An effect of antiseptics on the joints tissue growing organism requires further study, which is primarily due to the need of foresight and reducing the consequences of carried diseases. The aim. of the reserch is to determine the concentration of the octenidine dihydrochloride ("Octenisept"), antiseptics, whose effectiveness is proved concerning to a wide range of microorganisms, in which it can be used in septic diseases of the musculoskeletal system of the growing organism. The research of influence on the joints tissue the octenidine dihydrochloride in different partings studied in experiments on 40 immature 2-month-old white laboratory rats. Reactive and inflammatory changes, which expressed in different degrees, noted in the synovial layer of the animals‘ joint capsule, virtually in all animals in an experimental and control group. Significant differences observed in animals of the first control group (6 hours after washing the joint) where the thickness index of synovial layer, concerning the intact animals were by 16, 8 % higher. The thickness of the capsule was significantly higher than in the capsule of the intact animals and animals in the knee joint study group. Thus, in the group of animals where the joint was washed on octenidine dihydrochloride at 1:4 dilution, the thickness of the capsule was by 33.6 % more, in the group of animals with joint lavage octenidine dihydrochloride at a dilution of 1:3 through 6:00 capsule thickness values were (about intact animals) by 38.8 % higher, and after 12 hours - by 22.5 %. Based on the results obtained on the effect of octenidine dihydrochloride (taken at different dilutions) in the tissue of the knee joint, revealed that it has no toxic effect on articular cartilage and synovial membrane and other components of the joint. Using of the preparation at the 1:4 dilution does not cause inflammatory changes in the tissues of the joints, laboratory animals, allowing its using in this concentration in the treatment of inflammatory diseases of the musculoskeletal system in the growing organism.

Item Type: Article
Uncontrolled Keywords: octenidine dihydrochloride, metaepiphyseal osteomyelitis, experiment, joints, articular cartilage
Subjects: Anatomy
Experimental medicine
Divisions: Departments > Department of Human Anatomy
Departments > Department of Pediatric surgery, Traumatology and Orthopedics
Depositing User: Елена Шрамко
Date Deposited: 21 Nov 2018 12:04
Last Modified: 21 Nov 2018 12:04

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