Kuryata, O. and Zabida, A. and Тachenkо, V. (2017) The effekt of age difference on the serum level of advanced glycation end products in patients with post infarction heart failure. In: Materials of the XVIII National Congress of Cardiologists of Ukraine. Ukrainian Journal of Cardiology, 20-22вересня 2017, Київ.
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Abstract
post-infarction heart failure with preserved ejection fraction(HFpEF) determines a great morbidity and mortality, and given the physiopathology implications of advanced glycation end products (AGEs) in the genesis of myocardial dysfunction.Glycation refers to a non-enzymatic reaction of reducing sugars with the amino group of amino acids, nucleic acids, lipids and proteins .These targets of glycation processes undergo rearrangements to form stable heterogeneous compounds called AGEs. AGEs like pentosidine ,N-carboxymethyl-lysine (CML) are formed oxidatively (glycoxidation products), but methylglyoxal-derived hydroimidazolone MG-H1, the major AGE, is formed non-oxidatively.AGEs are end-products formed by oxidative and non-oxidative reactions between sugars and proteins. AGEs form cross-links with long-living tissue proteins, which cause them to accumulate in the body over time. AGEs can bind to the receptor of AGE (RAGE) and thereby induce cardiovascular dysfunction. RAGE has a C-truncated secretory isoform, soluble RAGE (sRAGE), that circulates in plasma. sRAGE has been proposed to have an atherosclerotic-protective function. However, AGE-RAGE interaction can also cause inflammation and increased AGE-accumulation. AGEaccumulation in turn can cause up regulation of RAGE. Through decreased compliance of the heart and the vasculature, AGE accumulation is considered to be related to the onset and progression of HF. As known endothelial dysfunction is an independent predictor for cardiovascular disease. L-Arginine is the amino acid with potential to improve endothelial function which leading to prevention and treatment of cardiovascular diseases, and we think that L-Arginine may decrease the serum AGEs. We aimed to estimate the value of AGEs in post-infarction HFpEF patients , and detect the effect of L-Arginine on the serum level of AGEs in post-infarction HFpEF pts.
| Item Type: | Conference or Workshop Item (Keynote) |
|---|---|
| Subjects: | Cardiology |
| Divisions: | Departments > Department of Internal Medicine 2 and phthisiology |
| Depositing User: | Оксана Мажуга |
| Date Deposited: | 29 Nov 2018 11:02 |
| Last Modified: | 29 Nov 2018 11:02 |
| URI: | http://repo.dma.dp.ua/id/eprint/3609 |
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