Clinical significance of changes in nitric oxide concentration in exhausted air in patients with COPD

Yefimova, N.O. and Yefimova, M.O. (2025) Clinical significance of changes in nitric oxide concentration in exhausted air in patients with COPD. Prospects and innovations of science, 51 (5). 2622- 2630. ISSN 2786-4952

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Abstract

The development of extrapulmonary effects of COPD is of important clinical and prognostic significance. Cardiovascular disorders are considered as one of the potential systemic manifestations of COPD, the earliest of which is endothelial dysfunction. In the last decade, the role of nitric oxide (NO) in the pathophysiology of respiratory diseases has been intensively studied, including as a marker of endothelial dysfunction. In COPD, there are enough factors that determine the development of endothelial dysfunction, such as hypoxia, increased levels of various biologically active substances, smoking, etc. In the modern literature, there are limited data on the study of the development of endothelial dysfunction and ventilation disorders in COPD patients who are not exposed to smoking and have an uncomplicated cardiovascular history. The aim of the study was to study the concentration of NO in exhaled air in non-smoking COPD patients without concomitant cardiovascular disease, depending on the severity of the disease in stable and exacerbations of COPD. 25 men with COPD (GOLD 1-4) in remission and exacerbation and 11 practically healthy men were examined. All of them had never smoked. The indicators of lung ventilation function and the concentration of NO in exhaled air were determined. It was found that both in the remission phas eand in exacerbations of COPD, the concentration of NO in exhaled air exceeds the average values of the indicator in the control group (p < 0.05). During exacerbation of COPD in patients with a mild course of the disease (GOLD 1-2), the level of NOin exhaled air increases compared to remission (p < 0.05), but in patients with severe manifestations of COPD (GOLD 3-4) the increase in the indicator was not significant (p > 0.05). During exacerbation of severe COPD (GOLD 3-4), a correlation was established between the concentration of NO in exhaled air and theduration of the disease (r = 0.67, p = 0.02). No relationship was found between thelevel of NO in exhaled air and the age of patients, the frequency of exacerbations per year, as well as indicators of lung ventilation function, regardless of the severity of the disea

Item Type:	Article
Additional Information:	DOI: 10.52058/2786-4952-2025-5(51)-2622-2630
Uncontrolled Keywords:	COPD, endothelial dysfunction, nitric oxide, smoking, exacerbation, remission
Subjects:	Family Medicine
Divisions:	Departments > Department of Internal Medicine
Depositing User:	Аліна Чеботарьова
Date Deposited:	06 Jun 2025 11:31
Last Modified:	06 Jun 2025 11:31
URI:	http://repo.dma.dp.ua/id/eprint/9448

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