Epigenetic influence of long non-coding RNAs on the development of metabolicly associated steatohepatitis

Abaturov, O.E. and Nikulina, A.O. (2025) Epigenetic influence of long non-coding RNAs on the development of metabolicly associated steatohepatitis. Eastern Ukrainian Medical Journal, 13 (3). pp. 606-621. ISSN 2664-4231 (Online), 2663-5909 (Print)

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Abstract

Metabolically associated steatohepatitis (MASH) is a progressive form of metabolically associated fatty liver disease (MAFLD), characterized by lobular liver inflammation. From a diagnostic point of view, lobular liver inflammation in patients with MAFLD is the main pathomorphological sign of the transition of simple hepatic steatosis to steatohepatitis. It has been demonstrated that various long non-coding RNAs play a significant role in the regulation of the response of both the innate and adaptive immune systems, participate in the regulation of proliferation, differentiation and activation of immune cells. Long noncoding RNAs are involved in the development of MAFLD, mainly by providing activity to pro-inflammatory signaling pathways, transcription factors (NF-κB, AP-1) and inflammasomes. Long noncoding RNAs, by regulating the expression level of cytokines (IL-1β, IL-6, TNF-a) and chemokines (CCL2, CXCL1, CXCL5), determine the recruitment of pro-inflammatory immunocytes, local vascular response and, as a consequence, the degree of inflammatory reaction of liver tissue in MAFLD. The state of the lncR transcriptome of structural liver cells, resident and recruited immune cells in the liver determines the likelihood of developing steatohepatitis in MAFLD. The results of deep sequencing of the new generation, carried out in mini-pigs, indicate that the induction of steatohepatitis is accompanied by differential expression of 89 lncRs, the main molecular targets of which are the genes Ppar, Fads2, Dgat2, Acaa2, Cyp2e1, Adh4 and Fos. Thus, pro-inflammatory and anti-inflammatory lncRs are epigenetic regulators of liver inflammation, which determine the development of MASH and are considered as potential targets for anti-inflammatory drug therapy of patients.

Item Type:	Article
Additional Information:	https://doi.org/10.21272/eumj.2025;13(3):606-621
Uncontrolled Keywords:	children, obesity, metabolically associated steatohepatitis, long non-coding RNA, literary review.
Subjects:	Endocrinology
Divisions:	Departments > Department of Pediatrics 1 and medical genetics (formerly - Faculty Pediatrics and Medical Genetics)
Depositing User:	Анастасия Жигар
Date Deposited:	19 Dec 2025 09:20
Last Modified:	19 Dec 2025 09:20
URI:	http://repo.dma.dp.ua/id/eprint/9660

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