Pediatric neuroinfection caused by Borrelia burgdorferi and Varicella-zoster virus: A case report

Shvaratska, Olha and Mavrutenkov, Victor and Mavrutenkova, Tatiana (2020) Pediatric neuroinfection caused by Borrelia burgdorferi and Varicella-zoster virus: A case report. Medical Science (№ 24). pp. 3413-3420. ISSN 2321-7359 (Print), 2321-7367(Online)

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Abstract

Background: Pediatric co-infections are an emerging problem due to their ascending prevalence and tendency to blur typical clinical presentation of particular diseases. Case presentation: The paper describes a verified case of Varicella-zoster virus and Borrelia burgdorferi co-infection in a 7-year-old male patient. Neuroinfection manifested ten days after the onset of varicella episode. Acyclovir IV was initiated for acute varicella zoster encephalitis. Concerned with the progression of neurological disorders we performed additional cerebrospinal fluid PCR testing for other potential neuropathogens; Borrelia burgdorferi DNA was detected. The patient denied any history of tick exposure. Combination of ceftriaxone and acyclovir IV was effective. Discussion: Co-infection with Varicella-zoster virus and B. burgdorferi may have a permissive deleterious impact on the central nervous system with unclear mechanisms. Testing for molecular biological and/or serological markers of Lyme disease should be a standard procedure in patients with any severe neuroinfection in endemic regions regardless of anamnestic data.

Item Type:	Article
Uncontrolled Keywords:	Varicella-zoster infection; Borrelia burgdorferi; Lyme disease; encephalitis; children
Subjects:	Infectious diseases
Divisions:	Departments > Department of Infectious Diseases Departments > Department of Pediatrics 3 and Neonatology (formerly - Hospital Pediatrics 2 and Neonatology)
Depositing User:	Анастасия Жигар
Date Deposited:	20 Jan 2021 11:38
Last Modified:	20 Jan 2021 11:38
URI:	http://repo.dma.dp.ua/id/eprint/6177

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