Мonitoring of enterobacteria strains with producing of β-lactamases in males with infectiousinflammatory diseases of urogenital tract

Sklyar, T.V. and Lavrentievа, K.V. and Kurahina, N.V. and Lykholat, T.Yu. and Papiashvil, M.G. and Lykholat, O.A. and Stepanskyi, D.O. (2022) Мonitoring of enterobacteria strains with producing of β-lactamases in males with infectiousinflammatory diseases of urogenital tract. Медичні перспективи = Medicni perspektivi (Medical perspectives) (2). pp. 110-118. ISSN 2307-0404 (print), 2786-4804 (online)

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Abstract

This article presents the findings of investigation of the microflora of 257 males with infectious-inflammatory diseases of the urogenital tract using the test system “Androflor”. The role of representatives of conditionally pathogenic microflora as the main etiological agent in occurrence of infectious-inflammatory diseases of the urogenital tract in males was shown. Its composition in 39.3±3.0% of cases was represented by bacteria of family Enterobacteriaceae, in 10.9±1.9% – by Enterococcus spp., in 3.1±1.1% – by Haemophilus spp. and in 0.4±0.1% of cases – by P. aeruginosa. Out of 101 strains of enterobacteria, 27 representatives had the ability to synthesize β-lactamases 26.7±4.4% of cultures), in particular: 16 isolates of E. coli, 5 isolates of P. mirabilis and 6 isolates of K. pneumoniae. The selected strains of enterobacteria producing β-lactamases appeared to be resistant at least to 6 tested antibiotics, which allowed referring them to categories of multi-resistant. All cultures producing β-lactamases showed resistance to penicillinеs – ampicillin and amoxiclav. In this case, resistance to at least one of the antibiotics of cephalosporin group of the third generation was noted. In addition, 83.3±2.1% of the examined isolates were characterized by resistance to macrolides – erythromycin and azithromycin, as well as to co-trimoxazole and fosfomicin. The obtained data are of practical importance to develop efficient schemes of antibiotic therapy for infectious-inflammatory diseases of the urogenital tract, caused by strains of enterobacteria producing β-lactamases

Item Type:	Article
Additional Information:	DOI: 10.26641/2307-0404.2022.2.260282
Uncontrolled Keywords:	opportunistic pathogenic microflora, urogenital tract, enterobacteria, β-lactamases, antibiotics, resistance; умовно-патогенна мікрофлора, урогенітальний тракт, ентеробактерії, β-лактамази, антибіотики, резистентність; условно-патогенная микрофлора, урогенитальный тракт, энтеробактерии, β-лактамазы, антибиотики; резистентность
Subjects:	Microbiology, Virology and Immunology Urology
Divisions:	Departments > Department of Microbiology, virology, immunology and epidemiology University periodicals > Medical perspectives
Depositing User:	Ирина Медведева
Date Deposited:	27 Feb 2023 09:04
Last Modified:	27 Feb 2023 09:04
URI:	http://repo.dma.dp.ua/id/eprint/8180

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