Broad-purpose antimicrobial chlorine-active polymers: suppression of multidrug-resistant microorganisms and microbial penetration resistance

Murashevych, B. and Koshova, I. and Surmasheva, O. and Girenko, D. and Chuiko, V. and Stepanskyi, D. (2022) Broad-purpose antimicrobial chlorine-active polymers: suppression of multidrug-resistant microorganisms and microbial penetration resistance. ScienceRise: Medical Science (5(39)). pp. 64-73. ISSN 2519-4798 (Online), 2519-478X (Print)

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Abstract

The aim of the work was to evaluate the antimicrobial activity of polymeric materials with immobilized N-Chloro-sulfonamide groups against multidrug-resistant hospital strains of common microorganisms and to determine the resistance to microbial penetration of these materials.Materials and methods: the studied samples were copolymers of styrene with divinylbenzene in the form of staple fi bre and non-woven fabric with immobilized N-Chlorosulfonamide groups of various structures. Hospital strains of microorganisms have been isolated from clinical material; their antibiotic sensitivity has been determined by the Kirby-Bauer method. The agar diff usion method determines the antimicrobial activity of the polymers. Resistance to microbial penetration of samples of non-woven fabric has been determined by the membrane fi ltration method.Results: polymer samples have been synthesized with immobilized N-Chlorosulfonamide groups in the Na- and H-forms, and with the N, N-dichlorosulfonamide group, with chlorine concentration range 3.7–12.5 %. All sam-ples demonstrated pronounced antimicrobial activity against both standard and hospital strains. Due to the higher specifi c surface area, staple fi bre is generally more effi cient. An increase in the zone of inhibition of the growth of microorganisms was observed with an increase in the concentration of immobilized chlorine. All the studied fabric samples are impermeable to S. aureus. The control samples containing the free sulfonamide group did not show antimicrobial properties.Conclusions: synthesized chlorine-active polymers have a pronounced antimicrobial activity against multi-drug-resistant microorganisms, demonstrate high resistance to microbial penetration and therefore are promising for creating a wide range of medical products on their basis: dressings, protective masks, antimicrobial fi lters, etc.

Item Type:	Article
Additional Information:	DOI: 10.15587/2519-4852.2022.266171
Uncontrolled Keywords:	antimicrobial polymers, active chlorine, N-Chlorosulfonamides, immobilization, antibiotic resistance, microbial penetration resistance, dressings, face masks
Subjects:	Microbiology, Virology and Immunology
Divisions:	Departments > Department of Biochemistry and medical chemistry Departments > Department of Medical and Biological Physics and Informatics
Depositing User:	Аліна Чеботарьова
Date Deposited:	14 Aug 2023 10:42
Last Modified:	14 Aug 2023 11:27
URI:	http://repo.dma.dp.ua/id/eprint/8511

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