Increased secretion of irisin hormone during physical exercise: a systematic review

Pembayun, N.S.R and Wibawa, J.C and Lobo, J. and Ardha, M.A.A. and Nurhasan and Hartati, S.C.Y. and Komaini, A. and Ayubi, N. (2025) Increased secretion of irisin hormone during physical exercise: a systematic review. Медичні перспективи, 30 (4). pp. 152-161. ISSN 2307-0404, online 2786-4804

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Abstract

Obesity is a medical condition characterized by the accumulation of excess fat in the body, which can increase the risk of various chronic diseases such as type 2 diabetes, hypertension, and heart disease. Obesity also correlates with an increase in metabolic syndrome diseases that have a negative impact on human health. The prevalence of obesity continues to increase globally, including in developing countries, along with changes in diet and lifestyle. Genetic, environmental, and behavioral factors play an important role in the development of obesity. The impact is not only limited to physical health, but also includes psychological and social aspects. Therefore, it is important to immediately address this problem. Irisin is one of the hormones that plays a major role in reducing obesity rates. The purpose of this study was to determine how physical exercise can increase the expression of the irisin hormone. For this study, a number of journal databases were searched, such as Pubmed, Embase, Science Direct, Web of Science, and Scopus. This study considered various variables, including research on physical activity and the irisin hormone published in journals in the last five years. The analysis included only publications from reputable scientific journals that met the established inclusion criteria, namely: the studies had to involve human participants, and the interventions had to consist of physical exercise. Using databases from Pubmed, Science Direct, Embase, Web of Science, and Scopus, 104 publications were found. Approximately ten carefully selected publications discussed the need for a systematic review analysis. The standard operating procedure for the investigation was developed using – preferred reporting items for systematic reviews and meta-analyses (PRISMA). The results of the systematic review showed an increase in irisin expression during physical activity. The limitation of this review only concerned the effect of physical activity on the irisin hormone. The best dose given during physical exercise to increase irisin expression is still not fully understood, therefore it is important to conduct further studies that discuss an adequate and optimal dose of physical activity to increase irisin.

Item Type:	Article
Additional Information:	DOI:10.26641/2307-0404.2025.4.348350 https://medpers.dmu.edu.ua/uk/2025-tom-xxx/no-4#pdf-17
Uncontrolled Keywords:	physical exercise, irisin, health, obesity
Subjects:	Obesity Physical exercises
Divisions:	University periodicals > Medical perspectives
Depositing User:	Аліна Чеботарьова
Date Deposited:	28 Apr 2026 11:37
Last Modified:	28 Apr 2026 12:43
URI:	http://repo.dma.dp.ua/id/eprint/9928

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