Cardio-and Neuroprotective Effects of Corvitin and 2-Oxoglutarate in Rats with Pituitrin-Isoproterenol-Induced Myocardial Damage

Tkachenko, V. and Kovalchuk, Y. and Bondarenko, N. and Bondarenko, O. and Ushakova, G. and Shevtsova, A. (2018) Cardio-and Neuroprotective Effects of Corvitin and 2-Oxoglutarate in Rats with Pituitrin-Isoproterenol-Induced Myocardial Damage. Biochemistry Research International, Sept.. pp. 1-11. ISSN 2090-2255(Online), 2090-2247 (Print)

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Abstract

Heart diseases, especially acute coronary syndrome (ACS), are among the most severe illnesses that often lead to death. Despitesignificant advances in the prevention and treatment of ACS, the incidence of the disease and its complications are very serious. +eimbalance between pro- and antioxidant systems, the formation of active carbonyl compounds, and the end products of glycation inthe blood and tissues are the key moments in the development of heart and neurological disorders leading to a change of behavioralresponses. So, the search for antioxidants with cardio- and neuroprotective effects is an urgent task. +is study was aimed atevaluating the effects of Corvitin and 2-oxoglutarate on physiological parameters, heart histology, and markers of carbonyl/oxidativestress of rats with pituitrin-isoproterenol-induced myocardial damage (PIMD). Increased sweating, tachycardia, significantly decreasedlocomotor and exploratory activity, changes of ECG, heart histology, and biochemical changes were observed in the PIMDgroup.+e administration of Corvitin or 2-OG led to the recovery of locomotor and cognitive activities of the rats, improvement inheart histology, a decrease in the levels of thiobarbituric acid reactive substances, advanced glycated end products, and variouschanges in the activity of the antioxidant enzymes, 6 days after PIMD. So, Corvitin and exogenous 2-OG show cardio- andneuroprotective effects through the decrease of carbonyl/oxidative stress and regulation of the activity of the antioxidant system.

Item Type: Article
Additional Information: doi.org/10.1155/2018/9302414
Uncontrolled Keywords: pituitrin-isoproterenol-induced myocardial damage, Corvitin, 2-oxoglutarate.
Subjects: Biological Chemistry
Pathological anatomy
Divisions: Departments > Department of Biochemistry, Medical and Pharmaceutical Chemistry
Departments > Department of Pathological Anatomy and Forensic Medicine
Depositing User: Оксана Мажуга
Date Deposited: 10 Jan 2020 13:16
Last Modified: 10 Jan 2020 13:16
URI: http://repo.dma.dp.ua/id/eprint/4761

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